hTNFR2/MC-38
CBPG0250
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| I. Background | |
| TNFR2（肿瘤坏死因子受体2，CD120b）是肿瘤坏死因子受体超家族成员，编码基因 位于人类1 号染色体1p36 .22 区域，编码439 个氨基酸的单程跨膜糖蛋白。其核心特征为 在免疫抑制细胞（如调节性T 细胞Tregs、髓源抑制性细胞MDSCs）及肿瘤细胞表面高表 达，而正常组织表达受限，顺利获得与肿瘤坏死因子（TNF）结合激活NF-κB、MAPK、 PI3K/Akt 等信号通路，介导细胞存活、增殖及免疫调节功能。 | |
| II. Introduction | |
| Host Cell: | MC-38 |
| Expressed gene: | TNFR2 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | DMEM+10%FBS+2 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| III. Description of Host Cell Line | |
| Organism: | Mus musculus, mouse |
| Tissue: | Colon |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| IV. Representative Data | |
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| V. In VIVO Data | |
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Index |
Content |
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Animal |
C57BL/6J, 7weeks, female |
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Implanted Position |
Subcutaneous (right flank region) |
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Injected Cell Numbers |
1×10^6/0.1ml |
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Matrix gel |
Without matrix gel |
1. Weight Change
Figure 2. hTNFR2/MC38 Mean Body Weight ± SEM.
2. Tumor Volume
Figure 3. hTNFR2/MC38 Mean Tumor Volume ± SEM.
NOTE：The above data was provided by Cobioer (cell data) and Truway Bio (in vivo data model).
